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Unlike most of the injectable peptides covered above, GHK-Cu has meaningful evidence for topical application its small enough to cross the stratum corneum and reach dermal fibroblasts at relevant concentrations

In the future, incorporation of gene-based therapeutics encapsulated in nanocarriers can further improve the lacunae in brain targeting via BBB modulating strategies

On the other hand, gain-of-function variants in ion channel genes, the most common mechanism leading to paroxysmal disease [essentially a leaky channel

Krajewska M, Kitada S, Winter JN, Variakojis D, Lichtenstein A, Zhai D, Cuddy M, Huang X, Luciano F, Baker CH, Kim H, Shin E, Kennedy S, Olson AH, Badzio A, Jassem J, Meinhold-Heerlein I, Duffy MJ, Schimmer AD, Tsao M, Brown E, Sawyers A, Andreeff M , Mercola D, Krajewski S, Reed JC